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Publications
Number | Category | Citation | Image |
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100 | Total Synthesis | Xu, B.†.; Zhang, Z.†.; Tantillo, D. J.;* Dai, M.* "Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement" J. Am. Chem. Soc. 2024, 146, 21250-21256. (†contributed equally) | ![]() |
99 | Total Synthesis | Ma, D.; Duran, P.; Al-Ahmad, R.; Hestehave, S.; Joa, M.; Alsbiei, O.; Rodríguez-Palma, E. J.; Li, Y.; Wang, S.; Khanna, R.;* Dai, M.* “C–H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of New Analogs in Osteoarthritis-related Pain Treatment” J. Am. Chem. Soc. 2024, 146, 16698-16705. Highlighted in Synfact, 08/2024 (Synfact of the Month) | ![]() |
98 | Total Synthesis | Rivera, M. E.; Li, L.; Kolisetti, A. (UG); Chi, N. (UG); Dai, M.* “9-Step Synthesis of (–)-Larikaempferic Acid Methyl Ester Enabled by Skeletal Rarrangement" Chem. Commun. 2024, 60, Featured in 2024 Pioneering Investigators and Chemical Communications HOT Articles 2024 | ![]() |
97 | ChemBio | Li, X.; Wang, D.; Yin, X.; Dai, M.; Staiger, C. J.;* Zhang, C.* “A Chemical Genetic Screen with the EXO70 Inhibitor Endosidin2 to Uncover Potential Modulators of Exocytosis in Arabidopsis” Plant Direct, 2024, 8, e592. | |
96 | ChemBio Imaging | Chen, Z.; Chen, F.; Lee, H. J.; Zhang, M.; Yin, X.; Dai, M.; Cheng, J.-X.* “LIPA-Driven Hydrolysis of Cholesteryl Arachidonate Promotes Cancer Metastasis via NF-κB” bioRxiv (DOI: https://doi.org/10.1101/2022.03.11.484042). | ![]() |
95 | Natural Product Drug Discovery | Liang, W.; Krabill, A. D.; Gallagher, K. S.; Muli, C.; Qu, Z.; Trader, D.; Zhang, Z.-Y.;* Dai, M.* “Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase” Tetrahedron, 2024, 156, 133918. (Invited contribution to the special issue in honor of Professor Thomas Maimone’s 2024 Tetrahedron Young Investigator Award in Organic Synthesis) | ![]() |
94 | Methodology | Fang, W.; Luo, Z.-W.; Wang, Y.-C.; Zhou, W.; Li, L.; Chen, Y.; Zhang, X.; Dai, M.;* Dai, J.-J.* “An SN2 reaction at amide nitrogen enables hydrazide synthesis”. Angew. Chem. Int. Ed. 2024, 63, e202317570. | ![]() |
93 | Total Synthesis | Jin, Y.; Hok, S.; Bacsa, J.; Dai, M.* “Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C-H Functionalizations” J. Am. Chem. Soc. 2024, 146, 1825-1831.. | ![]() |
92 | Total Synthesis | Jiang, B.; Dai, M.* "Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products". J. Am. Chem. Soc. 2023, 145, 18731-18736. | ![]() |
91 | Total Synthesis | Cui, C.; Dai, M.* "Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction". Chin. J. Chem. 2023, doi: 10.1002/cjoc.202300331. (Invited contribution dedicated to the Special Issue of C1 Chemistry). | ![]() |
90 | Total Synthesis | Martin, B. S.†; Ma, D.†; Saito, T.; Gallagher, K. S.; Dai, M.* "Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing". Synthesis, 2023, accepted (DOI: 10.1055/a-2107-5159). (†contributed equally) | ![]() |
89 | Total Synthesis | Cai, X.;† Li, L.;† Wang, Y.-C.; Zhou, J.; Dai, M.* "Total Syntheses of Phleghenrines A and C". Org. Lett. 2023, 25, 5258-5261. (†contributed equally) Previous deposit at ChemRxiv: ChemRxiv, May 26, 2023. DOI: 10.26434/chemrxiv-2023-8f4rz. | ![]() |
88 | Methodology Amination | Dai, J.-J;† Yin, X.;† Li, L.;† Rivera, M. E.; Wang, Y.-C.;* Dai, M.* " Modular and practical diamination of Allenes". Nature Communications, 2023, 14, 1774. (†contributed equally) | ![]() |
87 | Perspective | Sims, H. S.; Dai, M.* "Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments". J. Org. Chem. 2023, 88, 4925-4941. | ![]() |
86 | Spotlight | Sims, H. S.*; Dai, M.* "Taming PRMT5-adaptor protein interactions" Trends Pharmacol. Sci. 2023, 44, 134-136. | ![]() |
85 | Total Synthesis | Li, L.; Liang, W.; Rivera, M. E.; Wang, Y.-C.; Dai, M. "Concise Synthesis of (-)-GA18 Methyl Ester" J. Am. Chem. Soc. 2023, 145, 53-57. | ![]() |
84 | Total Synthesis | Xu, B.;† Liu, C.;† Dai, M.;* “Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A” J. Am. Chem. Soc. 2022, 144, 19700-19703. (†contributed equally) | ![]() |
83 | Drug Discovery Cancer | Asberry, A. M.†; Cai, X.†; Deng, X.†; Santiago, U.†; Liu, S.; Sims, H. S.; Liang, W.; Xu, X.; Wan, J.; Jiang, W.; Camacho, C.;* Dai, M.;* Hu, C.-D.* “Discovery and biological characterization of PRMT5:MEP50 protein-protein interaction inhibitors” J. Med. Chem. 2022, 65, 13793-13812. (†contributed equally) | ![]() |
82 | ChemBio Imaging | Clark, M. G.; Gonzalez, G.; Luo, Y.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G.; Dai, M. Zhang, C.* "Real-Time Precision Opto-Control of Chemical Processes in Live Cells" Nature Communications, 2022, 13, 4343. | ![]() |
81 | Methodology Nickel Catalysis | de Andrade Horn, P.; Sims, H. S. Dai, M.* "Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes" J. Org. Chem. 2022, 87, 8796-8801. | ![]() |
80 | Drug Discovery Cancer | Peery, R.; Cui, Q.; Kyei-Baffour, K.; Josephraj, S.; Huang, C.; Dong, Z.; Dai, M.;* Zhang, J.-T.* Liu, J.-Y.;* “A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells” Bioorg. Med. Chem. 2022, 65, 116761. | ![]() |
79 | Book Chapter Carbonylation | Luo, Y.; Li, L.; Dai, M.* “Complex Natural Products Total Syntheses Facilitated by Palladium-Catalyzed Carbonylative Cyclizations” in “The Chemical Transformations of C1 Compounds”, Volume 2, Chapter 18, 793-826, Book Editors: Kuling Ding, Xiao-Feng Wu, Buxing Han, Zhongmin Liu, Wiley. | ![]() |
78 | Total Synthesis | Sims, H. S.; de Andrade Horn, P.; Isshiki, R.; Lim, M. (UG); Xu, Y.; Grubbs, R. H.; Dai, M* "Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester" Angew. Chem. Int. Ed., 2022, 61, e202115633. | ![]() |
77 | Total Synthesis | Jiang, B.; Dai, M.* “11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C-H Functionalizations" J. Am. Chem. Soc. 2021, 143, 20084-20089. | ![]() |
76 | Total Synthesis | Ma, D.†; Martin, B. S.†; Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine” J. Am. Chem. Soc. 2021, 143, 16383-16387. (†contributed equally) | ![]() |
75 | Total Synthesis | Wang, Y.-C.†; Cui, C.†; Dai, M.* "Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A" Angew. Chem. Int. Ed. 2021, 60, 24828-24832. (†contributed equally) Selected as a Hot Paper; Featured as an Inside Cover; Highlighted by WileyChem. | ![]() |
74 | Drug Discovery Hypertension | Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension” Science Advances, 2021, 7:eabh3794. | ![]() |
73 | Drug Discovery Antibiotic | Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo” Sci. Rep. 2021, 11, 10913. | |
72 | Total Synthesis Target ID | Cui, C.†; Dwyer, B. G.†; Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes " J. Am. Chem. Soc. 2021, 143, 4379-4386. (†contributed equally.) Featured in Purdue News, ScienceDaily, NSF Research News, and others; Highlighted by X-MOL and Synfacts. | ![]() |
71 | ChemBio | Raffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118. | ![]() |
70 | Methodology Cyclopropanol | Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311. Highlighted by X-MOL | ![]() |
69 | Methodology Carbonylation Cyclopropanol | Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682. Highlighted by X-MOL and Synfacts | ![]() |
68 | Drug Discovery Antimalaria | Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678. | ![]() |
67 | Total Synthesis | Yin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004. | ![]() |
66 | Drug Discovery Cancer | Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251. | ![]() |
65 | Total Synthesis | Jiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179. | ![]() |
64 | ChemBio | Huang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157. | |
63 | Material Chemistry | Oleson, A.; Zhu, T.; Dunn, I.; Bialas, D.; Bai, Y.; Zhang, W.; Dai, M.; Reichman, D.; Tempelaar, R.; Huang, L.; Spano, F.* “Perylene Diimide- Based Hj- and hJ-Aggregates: The Prospect of Exciton Band Shape Engineering in Organic Materials” J. Phys. Chem. C 2019, 123, 20567-20578. | |
62 | ChemBio | Huang, L.; Li, X.; Li, Y.; Yin, X.; Li, Y.; Wu, B.; Mo, H.; Liao, C.; Mengiste, T.; Guo, W.; Dai, M.; Zhang, C.* “Endosidin2-14 targets the exocyst complex in plants and fungal pathogens to inhibit exocytosis” Plant Physiology 2019,180, 1756-1770. | |
61 | Drug Discovery Antibiotic | Mohammad, H.†; Kyei-Baffour, K.†; Abutaleb, N. S.; Dai, M.*; Seleem, M.* "An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection" J. Glob. Antimicrob. Resist. 2019, 1-7 (doi:10.1016/j.jgar.2019.04.016). (†contributed equally) | ![]() |
60 | Drug Discovery Antibiotic | Kyei-Baffour, K.†; Mohammad, H.†; Seleem, M.*; Dai, M.* "Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus" Bioorg. Med. Chem. 2019, 27, 1845-1854. (†contributed equally) | ![]() |
59 | Total Synthesis | Luo, Y.; Yin, X.; Dai, M.* "Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation" J. Antibiotics 2019, 72, 482-485. (Special Issue dedicated to Professor Samuel J. Danishefsky) | ![]() |
58 | Review Cyclopropanol | Cai, X.; Liang, W.; Dai, M.* "Total Syntheses via Cyclopropanols" Tetrahedron 2019, 75, 193-208. (Invited Special Issue Paper: Recent Applications of Metal Catalysis in Natural Product Synthesis. Guest Editors: Jeremy May and John Wood) | ![]() |
57 | Total Synthesis Target ID | Davis, D. C.†; Hoch, D. G.†; Wu, L.; Abegg, D.; Martin, B. S. Zhang, Z.-Y.*; Adibekian, A.*; Dai, M.* "Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids" J. Am. Chem. Soc. 2018, 140, 17465-17473. (†These authors contributed equally.) | ![]() |
56 | Total Synthesis | Ma, K.†; Yin, X. L.†; Dai, M.* "Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization" Angew. Chem. Int. Ed. 2018, 57, 15209-15212. (†contributed equally.) Highlighted by Synfacts. | ![]() |
55 | Review Total Synthesis | Cai, X.; Bai, Y.; Dai, M.* "Total Syntheses of Spinosyn A" Synlett 2018, 2623-2632. (Invited Synlett Account contribution by Prof. Peter Vollhardt) | ![]() |
54 | Review Total Synthesis Carbonylation | Ma, K.†; Martin, B. S.†; Yin, X. L.†; Dai, M.* "Natural Product Syntheses via Carbonylative Cyclizations" Nat. Prod. Rep. 2019, 36, 174-219. (†contributed equally) Highlighted by X-MOL. | ![]() |
53 | Methodology Cyclopropanol | Ye, Z.†; Cai, X.†; Li, J. (UG), Dai, M.* "Catalytic Cyclopropanol Ring Opening for Divergent Syntheses of gamma-Butyrolactones and delta-Ketoesters Containing All-Carbon Quaternary Centers" ACS Catalysis 2018, 8, 5907-5914. (†contributed equally) Highlighted by X-MOL. | ![]() |
52 | Methodology Amination | Ye, Z.; Adhikari, S.; Xia, Y.*; Dai, M.* "Expedient Syntheses of N-Heterocycles via Intermolecular Amphoteric Diamination of Allenes" Nature Communications 2018, 9, 721. Highlighted by X-MOL and Synfacts. | ![]() |
51 | Review | Li, Y.; Yin, X. L.; Dai, M.* "Catalytic Macrolactonizations for Natural Product Synthesis" Nat. Prod. Rep. 2017, 34, 1185-1192. Featured as Front Cover. | ![]() |
50 | Total Synthesis | Li, Y.; Dai, M.* "Total Syntheses of the Reported Structures of Curcusone I and J through Tandem Gold Catalysis" Angew. Chem. Int. Ed. 2017, 56, 11624-11627. Highlighted by X-MOL and Synfacts. | ![]() |
49 | Methodology Carbonylation | Yin, X.; Mohammad, H.; Eldesouky, H. E.; Abdelkhalek, A.; Seleem, M. N.;* Dai, M.* "Rapid Syntheses of Bicyclic Lactones via Palladium-Catalyzed Aminocarbonylative Lactonizations" Chem. Commun. 2017, 53, 7238-7241 (Invited contribution to the ChemComm Emerging Investigators Issue 2017). Highlighted by X-MOL. | ![]() |
48 | Drug Discovery Antibiotic | Mohammad, H.†; Kyei-Baffour, K.†; Younis, W.; Davis, D. C.; Eldesouky, H.; Seleem, M. N.;* Dai, M.* "Investigation of Aryl Isonitrile Compounds with Potent, Broad-spectrum Antifungal Activity" Bioorg. Med. Chem. 2017, 25, 2926-2931. (†contributed equally; Invited contribution in honor of Professor Xiaoguang Lei’s Tetrahedron Young Investigator Award 2017). | ![]() |
47 | Review Carbonylation | Bai, Y.; Davis, D. C.; Dai, M.* "Natural Product Synthesis via Palladium-Catalyzed Carbonylation" J. Org. Chem., 2017, 82, 2319-2328 (Invited JOCSynopsis contribution by Professor Dale Poulter). | ![]() |
46 | Drug Discovery Pain | Brust, T. F.; Alongkronrusmee, D.; Soto-Velasquez, M.; Baldwin, T. A.; Ye, Z.; Dai, M.; Dessauer, C. W.; van Rijn, R. M.; Watts, V. J.* "Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties" Science Signaling, 2017, 10, eaah5381. Highlighted by Science News Story. | ![]() |
45 | Review Heterocycles | Gettys, K. E.; Ye, Z.; Dai, M.* "Recent Advances in Piperazine Synthesis" Synthesis, 2017, 49, 2589-2604 (Invited review article by Professor Dieter Enders). | ![]() |
44 | Methodology Cyclopropanol | Davis, D. C.; Haskins, C. W.; Dai, M.* "Radical Cyclopropanol Ring Opening Initiated Tandem Cyclizations for Efficient Synthesis of Phenanthridines and Oxindoles" Synlett, 2017, 28, 913-918 (Invited contribution for the special issue dedicated to the EuCheMS Young Investigator Workshop 2016). | ![]() |
43 | Total Synthesis | Li, Y.; Wei, M. (UG); Dai, M.* "Gold Catalysis-Facilitated Rapid Synthesis of the Daphnane/Tigliane Tricyclic Core" Tetrahedron, 2017, 73, 4172-4177 (Invited contribution the "New Advances in Pericyclic Reactions" Symposium-in-Print guest-edited by Prof. Uttam Tambar). | ![]() |
42 | Editorial | Dai, M.* “Harnessing Molecular Strain in Organic Synthesis and Related Fields” Curr. Org. Chem. 2016, 20, 1850-1850. | |
41 | Total Synthesis | Bai, Y.; Shen, X. (UG); Li, Y.; Dai, M.* "Total Synthesis of Spinosyn A via Carbonylative Macrolactonization" J. Am. Chem. Soc. 2016, 138, 10838-10841. Highlighted by Synfacts and in the Today’s Topic of the Agricultural Chemical Society of Japan: 2017, Vol. 55, No. 8, 523-525. | ![]() |
40 | Total Synthesis Methodology Carbonylation | Davis, D. C.; Walker, K. L.; Hu, C.; Zare, R. N.; Waymouth, R. M.*; Dai, M.* "Catalytic Carbonylative Spirolactonization of Hydroxycyclopropanols" J. Am. Chem. Soc. 2016, 138, 10693-10699. Highlighted by Organic Chemistry Portal. | ![]() |
39 | Review Heterocycles | Ye, Z.; Gettys, K. E.; Dai, M.* "Opportunities and Challenges for Direct C-H Functionalization of Piperazines" Beilstein J. Org. Chem. 2016, 12, 702-715. (Invited for the Thematic Series "C-H Functionalization/Activation in Organic Synthesis"; Guest Editor: Prof. Richmond Sarpong) | ![]() |
38 | Reaction Mechanism | Lin, Z.; Tan, L.; Yang Y.; Dai, M.; Tureček, F.*, Ouyang, Z.,* and Xia, Y.* "Gas-Phase Reactions of Cyclopropenylidene with Protonated Alkyl Amines" Analyst 2016, 2412-2417. | ![]() |
37 | Methodology Cyclopropanol | Ye, Z.; Gettys, K. E.; Shen, X. (UG); Dai, M.* "Copper-Catalyzed Cyclopropanol Ring Opening Csp3-Csp3 Cross Couplings with (Fluoro)Alkyl Halides" Org. Lett. 2015, 17, 6074-6077. | ![]() |
36 | ChemBio | Chou, D. H.-C.; Vetere, A.; Choudhary, A.; Scully, S. S.; Schenone, M.; Tang, A.; Gomez, R.; Burns, S. M.; Lundh, M.; Vital, T.; Comer, E.; Faloon, P. W.; Dancik, V.; Ciario, C.; Paulk, J.; Dai, M.; Reddy, C.; Sun, H.; Young, M.; Donato, N.; Jaffe, J.; Clemons, P. A.; Palmer, M.; Carr, S. A.; Schreiber, S. L.; Wagner, B. K.* "Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling" J. Am. Chem. Soc. 2015, 137, 7929-7934. | ![]() |
35 | Drug Discovery Antibiotic | Davis, D. C.†; Mohammad, H.†; Kyei-Baffour, K.; Younis, W.; Creemer, C. N. (UG); Seleem, M. N.*; Dai, M.* "Discovery and Characterization of Aryl Isonitriles as A New Class of Compounds versus Methicillin- and Vancomycin-resistant Staphylococcus aureus" Eur. J. Med. Chem. 2015, 101, 384-390. (†contributed equally) | ![]() |
34 | Review Total Synthesis | Bai, Y.; Dai, M.* "Strategies and Methods for the Synthesis of Anti-Cancer Natural Product Neopeltolide and Its Analogs" Curr. Org. Chem. 2015, 19, 871-885. (Invited contribution) | ![]() |
33 | Methodology Cyclopropanol | Ye, Z.; Dai, M.* "An Umpolung Strategy for the Synthesis of beta-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols" Org. Lett. 2015, 17, 2190-2193. Highlighted by X-MOL. | ![]() |
32 | Methodology Cyclopropanol | Li, Y.†; Ye, Z.†; Bellman, T. M.; Chi, T. (UG); Dai, M.* "Efficient Synthesis of beta-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols" Org. Lett. 2015, 17, 2186-2189. (†contributed equally) Highlighted by X-MOL and Synfacts. | ![]() |
31 | Methodology Pd Catalysis | Ye, Z.; Brust, T. F.; Watts, V. J.*; Dai, M.* "Palladium-Catalyzed Regio- and Stereoselective gamma-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors" Org. Lett. 2015, 17, 892-895. | ![]() |
30 | ChemBio Imaging | Lee, H. J.†; Zhang, W.(UG)†; Zhang, D.; Yang, Y.; Liu, B.; Barker, E. L; Buhman, K. K.; Slipchenko, L. V.; Dai, M.*; Cheng, J.-X.* "Assessing Cholesterol Storage in Live Cells and C. elegans by SRS Imaging of Phenyl-Diyne Cholesterol" Sci. Rep. 2015, 5, 7930. doi:10.1038/srep07930. (†contributed equally) | ![]() |
29 | Highlight | Dai, M.* Bai, Y.; Dexter, D. C.; “Synthesis of tetrahydropyran- or tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations” Synthesis, 2014, 46, A120-A121 (Synform 2014/09). | |
28 | Total Synthesis | Yang, Y.†; Bai, Y.†; Sun, S.(UG); Dai, M.* "Biosynthetically Inspired Divergent Approach to Monoterpene Indole Alkaloids: Total Synthesis of Mersicarpine, Leuconodines B and D, Leuconoxine, Melodinine E, Leuconolam, and Rhazinilam" Org. Lett. 2014, 16, 6216-6219. (†contributed equally) Top 20 most read article in Organic Letters November 2014; The 2015 Organic Letters Outstanding Author of the Year Lectureship Award winning paper; Highlighed by Synfacts. | ![]() |
27 | Methodology Pd Catalysis | Zhang, W. (UG)†; Haskins, C. W.†; Yang, Y.; Dai, M.* "Synthesis of Nitriles via Palladium-Catalyzed Water Shuffling From Amides to Acetonitrile" Org. Biomol. Chem. 2014, 12, 9109-9112. (†contributed equally) | ![]() |
26 | Review Total Synthesis | Yang, Y.; Dai, M.* "Total Synthesis of Lyconadins:Finding Efficiency and Diversity" Synlett 2014, 25, 2093-2098. (Invited contribution) | ![]() |
25 | Total Synthesis Methodology Carbonylation | Bai, Y.; Davis, D. C.; Dai, M.* "Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonization" Angew. Chem. Int. Ed. 2014, 53, 6519-6522 (selected as a Very Important Paper). Featured in SYNFORM and highlighted by Organic Chemistry Portal. | ![]() |
24 | Total Synthesis | Yang, Y.; Haskins, C. W.; Zhang, W. (UG); Low, P. L. (UG); Dai, M.* "Divergent total syntheses of lyconadins A and C" Angew. Chem. Int. Ed. 2014, 53, 3922-3925. Highlighted by Organic Chemistry Portal and Amphoteros. | ![]() |
23 | Drug Discovery Cancer | Boskovic, Z. V.; Hussain, M. M.; Adams, D. J.; Dai, M., Schreiber, S. L. "Synthesis of piperlogs and analysis of their effects on cells" Tetrahedron, 2013, 69, 7559-7567. (Special issue to honor Professor Paul Wender on his receipt of the 2012 Tetrahedron Prize for Creativity in Organic Chemistry) | ![]() |
22 | Drug Discovery Cancer | Hartwell, K. A.; Miller, P. G.; Mukherjee, S.; Kahn, A. R.; Stewart, A. L.; Logan, D. J.; Negri, J. M.; Duvet, M.; Järås, M.; Puram, R.; Dancik, V.; Al-Shahrour, F.; Kindler, T.; Tothova, Z.; Chattopadhyay, S.; Hasaka, T.; Narayan, R.; Dai. M.; Huang, C.; Shterental, S.; Chu, L. P.; Haydu J. K.; Shieh, J. H.; Steensma, D. P.; Munoz, B.; Bittker, J.; Shamji, A. F.; Clemons, P.; Tolliday, N. J.; Carpenter, A. E.; Gilliland, D. G.; Stern, A. M.; Moore, M. A. S.; Scadden, D. T.; Schreiber, S. L.; Ebert, B. L.; Golub, T. R. "Niche-based screening identifies small-molecule inhibitors of leukemia stem cells" Nat. Chem. Bio., 2013, 9, 840-848. | |
21 | Book Chapter | Dai. M.*; Boskovic, Z. "Ruthenium complex of N,N’,N",-trimethyl-1,4,7-triazacyclononane and ruthenium complexes of cis-diaquabis (6,6’-dichloro-2,2’-bipyridine)", first update, Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents (Ed. Fuchs, P. L.), Wiley, 2013, 561-565. | |
20 | ChemBio Drug Discovery Cancer | Adams, D. J.†; Dai, M.†; Pellegrino, G.; Wagner, B. K.; Stern, A. M.; Shamji, A. F.; Schreiber, S. L. "Synthesis, Cellular Evaluation, and Mechanism of Action of Piperlongumine Analogs" Proc. Natl. Acad. Sci. USA, 2012, 109, 15115. (†contributed equally) | ![]() |
19 | Methodology Diels-Alder reaction | Peng, F.; Dai, M.; Angeles, A. R.; Danishefsky, S. J. "Permuting Diels-Alder and Robinson Annulation Stereopatterns" Chem. Sci. 2012, 3, 3076. (The 4th most-Accessed Article: August, 2012.) | ![]() |
18 | Total Synthesis | Wang, Z.; Dai, M.; Park, P. K.; Danishefsky, S. J. "Synthetic studies toward (+)-cortistatin A" Tetrahedron, 2011, 67, 10249. (Special issue dedicated to Professor Gilbert Stork’s 90th birthday.) | ![]() |
17 | Methodology Gold Catalysis | Luo, T.; Dai, M.; Zheng, S-L.; Schreiber, S. L. "Synthesis of α-Pyrones by Gold-Catalyzed Coupling Reactions" Org. Lett. 2011, 13, 2834. | ![]() |
16 | Methodology Computation Diels-Alder reaction | Hayden, A. E.; DeChancie, J.; George, A. H.; Dai, M.; Yu, M. L.; Danishefsky, S. J.; Houk, K. N "Origins of the Regioselectivities in the Diels−Alder Reactions of Vinylindenes with 1,4-Quinone Monoketal and Acrolein Dienophiles" J. Org. Chem. 2009, 74, 6770. | ![]() |
15 | Total Synthesis | Dai, M.; Danishefsky, S. J. "An oxidative dearomatization cyclization model for cortistatin A" Heterocycles 2009, 77, 157. (Special issue dedicated to Dr. Keiichiro Fukumoto’s 75th birthday) | ![]() |
14 | Total Synthesis | Dai, M.; Krauss, J. I.; Danishefsky, S. J. "Total synthesis of Spirotenuipesines A and B" J. Org. Chem. 2008, 73, 9576. (Special issue in the memory of Professor A. I. Meyers.) | ![]() |
13 | Total Synthesis Methodology | Dai, M.; Wang, Z.; Danishefsky, S. J. "A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6613. | ![]() |
12 | Total Synthesis | Dai, M.; Danishefsky, S. J. "A concise synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6610. | ![]() |
11 | Total Synthesis | Lei, X. G.; Dai, M.; Hua, Z. H.; Danishefsky, S. J. "Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers" Tetrahedron Lett. 2008, 49, 6383. | ![]() |
10 | Total Synthesis | Li. Z. T.; Gao, Y. X.; Tang, Y. F.; Dai, M.; Wang G. X.; Wang, Z. D.; Yang, Z. "Total synthesis of crisamicin A" Org. Lett. 2008, 10, 3017. | ![]() |
9 | Total Synthesis | Dai, M.; Danishefsky, S. J. "The total synthesis of spirotenuipesines A and B" J. Am. Chem. Soc. 2007, 129, 3498. The 3rd most-Accessed Articles: January-March, 2007; the 6th most-Accessed Articles: 2007; Highlighted by JACS Virtual Issue "The Synthesis of Biologically Active Natural Products" J. Am. Chem. Soc. 2008, 130, 6654; Highlighted by Synfacts, 2007, 08, 0783. | ![]() |
8 | Methodology Diels-Alder reaction | Dai, M.; Sarlah, D.; Yu, M. L.; Danishefsky, S. J.; Jones, G. J.; Houk, K. N. "Highly selective Diels-Alder reactions of directly connected enyne dienophiles" J. Am. Chem. Soc. 2007, 129, 645. Highlighted by Organic Chemistry Portal ID: J48-Y2007-0160. | ![]() |
7 | Methodology Diels-Alder reaction | Liu, Y. X.; Lu, K.; Dai, M.; Wang, K.; Wu, W. Q.; Chen, J. H.; Quan, J. M.; Yang, Z. "An efficient one-pot asymmetric synthesis of biaryl compounds via Diels-Alder/retro-Diels-Alder cascade reactions" Org. Lett. 2007, 9, 805. | ![]() |
6 | Total Synthesis | Tang, Y. F.; Zhang, Y. D.; Dai, M.; Luo, T. P.; Deng, L. J.; Chen, J. H.; Yang, Z. "A highly efficient synthesis of the FGH ring of micrandilactone A: Application of thioureas as ligands in the Co-catalyzed Pauson-Khand reaction and Pd-catalyzed carbonylative annulation" Org. Lett. 2005, 7, 885. | ![]() |
5 | Methodology Pd Catalysis | Liang, B.; Dai, M.; Chen. J. H.; Yang, Z. "Copper-free Sonogashira coupling reaction with PdCl2 in water under aerobic conditions" J. Org. Chem. 2005, 70, 391. The 10th most-Accessed Articles: January-March, 2005; the 12th most-Accessed Articles: 2005; Highlighted by Organic Chemistry Portal ID: J42-Y2005-090. | ![]() |
4 | Methodology Pd Catalysis | Xiong, Z.-C.; Wang, N.-D.; Dai, M.; Li, A.; Chen. J. H.; Yang, Z. "Synthesis of novel palladacycles and their application in the Heck and Suzuki reaction under aerobic conditions" Org. Lett. 2004, 6, 3337. | ![]() |
3 | Methodology Pd Catalysis | Dai, M.; Liang, B.; Wang, C. H.; You, Z. J.; Xiang, J.; Dong, G. B.; Chen. J. H.; Yang, Z. "A novel thiourea ligand applied in Heck, Suzuki and Suzuki carbonylative reactions" Adv. Synth. Catal. 2004, 346, 1669. | ![]() |
2 | Methodology Pd Catalysis | Dai, M.; Liang, B.; Wang, C. H.; Chen. J. H.; Yang, Z. "Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions" Org. Lett. 2004, 6, 221. | ![]() |
1 | Methodology Pd Catalysis | Dai, M.; Wang, C. H.; Dong, G. B.; Xiang, J.; Luo, T. P.; Liang, B.; Chen. J. H.; Yang, Z. "Development of thiourea-based ligands for the palladium-catalyzed bis(methoxycarbonylation) of terminal olefins" Eur. J. Org. Chem. 2003, 4346. | ![]() |