Number	Category	Citation	Image
92	Total Synthesis	Jiang, B.; Dai, M.* "Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products". J. Am. Chem. Soc. 2023, 145, 18731-18736.
91	Total Synthesis	Cui, C.; Dai, M.* "Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction". Chin. J. Chem. 2023, doi: 10.1002/cjoc.202300331. (Invited contribution dedicated to the Special Issue of C1 Chemistry).
90	Total Synthesis	Martin, B. S.†; Ma, D.†; Saito, T.; Gallagher, K. S.; Dai, M.* "Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing". Synthesis, 2023, accepted (DOI: 10.1055/a-2107-5159). (†contributed equally)
89	Total Synthesis	Cai, X.;† Li, L.;† Wang, Y.-C.; Zhou, J.; Dai, M.* "Total Syntheses of Phleghenrines A and C". Org. Lett. 2023, 25, 5258-5261. (†contributed equally) Previous deposit at ChemRxiv: ChemRxiv, May 26, 2023. DOI: 10.26434/chemrxiv-2023-8f4rz.
88	Methodology Amination	Dai, J.-J;† Yin, X.;† Li, L.;† Rivera, M. E.; Wang, Y.-C.;* Dai, M.* " Modular and practical diamination of Allenes". Nature Communications, 2023, 14, 1774. (†contributed equally)
87	Perspective	Sims, H. S.; Dai, M.* "Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments". J. Org. Chem. 2023, 88, 4925-4941.
86	Spotlight	Sims, H. S.*; Dai, M.* "Taming PRMT5-adaptor protein interactions" Trends Pharmacol. Sci. 2023, 44, 134-136.
85	Total Synthesis	Li, L.; Liang, W.; Rivera, M. E.; Wang, Y.-C.; Dai, M. "Concise Synthesis of (-)-GA18 Methyl Ester" J. Am. Chem. Soc. 2023, 145, 53-57.
84	Total Synthesis	Xu, B.;† Liu, C.;† Dai, M.;* “Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A” J. Am. Chem. Soc. 2022, 144, 19700-19703. (†contributed equally)
83	Drug Discovery Cancer	Asberry, A. M.†; Cai, X.†; Deng, X.†; Santiago, U.†; Liu, S.; Sims, H. S.; Liang, W.; Xu, X.; Wan, J.; Jiang, W.; Camacho, C.;* Dai, M.;* Hu, C.-D.* “Discovery and biological characterization of PRMT5:MEP50 protein-protein interaction inhibitors” J. Med. Chem. 2022, 65, 13793-13812. (†contributed equally)
82	ChemBio Imaging	Clark, M. G.; Gonzalez, G.; Luo, Y.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G.; Dai, M. Zhang, C.* "Real-Time Precision Opto-Control of Chemical Processes in Live Cells" Nature Communications, 2022, 13, 4343.
81	Methodology Nickel Catalysis	de Andrade Horn, P.; Sims, H. S. Dai, M.* "Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes" J. Org. Chem. 2022, 87, 8796-8801.
80	Drug Discovery Cancer	Peery, R.; Cui, Q.; Kyei-Baffour, K.; Josephraj, S.; Huang, C.; Dong, Z.; Dai, M.;* Zhang, J.-T.* Liu, J.-Y.;* “A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells” Bioorg. Med. Chem. 2022, 65, 116761.
79	Book Chapter Carbonylation	Luo, Y.; Li, L.; Dai, M.* “Complex Natural Products Total Syntheses Facilitated by Palladium-Catalyzed Carbonylative Cyclizations” in “The Chemical Transformations of C1 Compounds”, Volume 2, Chapter 18, 793-826, Book Editors: Kuling Ding, Xiao-Feng Wu, Buxing Han, Zhongmin Liu, Wiley.
78	Total Synthesis	Sims, H. S.; de Andrade Horn, P.; Isshiki, R.; Lim, M. (UG); Xu, Y.; Grubbs, R. H.; Dai, M* "Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester" Angew. Chem. Int. Ed., 2022, 61, e202115633.
77	Total Synthesis	Jiang, B.; Dai, M.* “11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C-H Functionalizations" J. Am. Chem. Soc. 2021, 143, 20084-20089.
76	Total Synthesis	Ma, D.†; Martin, B. S.†; Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine” J. Am. Chem. Soc. 2021, 143, 16383-16387. (†contributed equally)
75	Total Synthesis	Wang, Y.-C.†; Cui, C.†; Dai, M.* "Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A" Angew. Chem. Int. Ed. 2021, 60, 24828-24832. (†contributed equally) Selected as a Hot Paper; Featured as an Inside Cover; Highlighted by WileyChem.
74	Drug Discovery Hypertension	Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension” Science Advances, 2021, 7:eabh3794.
73	Drug Discovery Antibiotic	Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo” Sci. Rep. 2021, 11, 10913.
72	Total Synthesis Target ID	Cui, C.†; Dwyer, B. G.†; Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes " J. Am. Chem. Soc. 2021, 143, 4379-4386. (†contributed equally.) Featured in Purdue News, ScienceDaily, NSF Research News, and others; Highlighted by X-MOL and Synfacts.
71	ChemBio	Raffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118.
70	Methodology Cyclopropanol	Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311. Highlighted by X-MOL
69	Methodology Carbonylation Cyclopropanol	Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682. Highlighted by X-MOL and Synfacts
68	Drug Discovery Antimalaria	Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678.
67	Total Synthesis	Yin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004.
66	Drug Discovery Cancer	Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251.
65	Total Synthesis	Jiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179.
64	ChemBio	Huang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157.
63	Material Chemistry	Oleson, A.; Zhu, T.; Dunn, I.; Bialas, D.; Bai, Y.; Zhang, W.; Dai, M.; Reichman, D.; Tempelaar, R.; Huang, L.; Spano, F.* “Perylene Diimide- Based Hj- and hJ-Aggregates: The Prospect of Exciton Band Shape Engineering in Organic Materials” J. Phys. Chem. C 2019, 123, 20567-20578.
62	ChemBio	Huang, L.; Li, X.; Li, Y.; Yin, X.; Li, Y.; Wu, B.; Mo, H.; Liao, C.; Mengiste, T.; Guo, W.; Dai, M.; Zhang, C.* “Endosidin2-14 targets the exocyst complex in plants and fungal pathogens to inhibit exocytosis” Plant Physiology 2019,180, 1756-1770.
61	Drug Discovery Antibiotic	Mohammad, H.†; Kyei-Baffour, K.†; Abutaleb, N. S.; Dai, M.*; Seleem, M.* "An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection" J. Glob. Antimicrob. Resist. 2019, 1-7 (doi:10.1016/j.jgar.2019.04.016). (†contributed equally)
60	Drug Discovery Antibiotic	Kyei-Baffour, K.†; Mohammad, H.†; Seleem, M.*; Dai, M.* "Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus" Bioorg. Med. Chem. 2019, 27, 1845-1854. (†contributed equally)
59	Total Synthesis	Luo, Y.; Yin, X.; Dai, M.* "Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation" J. Antibiotics 2019, 72, 482-485. (Special Issue dedicated to Professor Samuel J. Danishefsky)
58	Review Cyclopropanol	Cai, X.; Liang, W.; Dai, M.* "Total Syntheses via Cyclopropanols" Tetrahedron 2019, 75, 193-208. (Invited Special Issue Paper: Recent Applications of Metal Catalysis in Natural Product Synthesis. Guest Editors: Jeremy May and John Wood)
57	Total Synthesis Target ID	Davis, D. C.†; Hoch, D. G.†; Wu, L.; Abegg, D.; Martin, B. S. Zhang, Z.-Y.*; Adibekian, A.*; Dai, M.* "Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids" J. Am. Chem. Soc. 2018, 140, 17465-17473. (†These authors contributed equally.)
56	Total Synthesis	Ma, K.†; Yin, X. L.†; Dai, M.* "Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization" Angew. Chem. Int. Ed. 2018, 57, 15209-15212. (†contributed equally.) Highlighted by Synfacts.
55	Review Total Synthesis	Cai, X.; Bai, Y.; Dai, M.* "Total Syntheses of Spinosyn A" Synlett 2018, 2623-2632. (Invited Synlett Account contribution by Prof. Peter Vollhardt)
54	Review Total Synthesis Carbonylation	Ma, K.†; Martin, B. S.†; Yin, X. L.†; Dai, M.* "Natural Product Syntheses via Carbonylative Cyclizations" Nat. Prod. Rep. 2019, 36, 174-219. (†contributed equally) Highlighted by X-MOL.
53	Methodology Cyclopropanol	Ye, Z.†; Cai, X.†; Li, J. (UG), Dai, M.* "Catalytic Cyclopropanol Ring Opening for Divergent Syntheses of gamma-Butyrolactones and delta-Ketoesters Containing All-Carbon Quaternary Centers" ACS Catalysis 2018, 8, 5907-5914. (†contributed equally) Highlighted by X-MOL.
52	Methodology Amination	Ye, Z.; Adhikari, S.; Xia, Y.*; Dai, M.* "Expedient Syntheses of N-Heterocycles via Intermolecular Amphoteric Diamination of Allenes" Nature Communications 2018, 9, 721. Highlighted by X-MOL and Synfacts.
51	Review	Li, Y.; Yin, X. L.; Dai, M.* "Catalytic Macrolactonizations for Natural Product Synthesis" Nat. Prod. Rep. 2017, 34, 1185-1192. Featured as Front Cover.
50	Total Synthesis	Li, Y.; Dai, M.* "Total Syntheses of the Reported Structures of Curcusone I and J through Tandem Gold Catalysis" Angew. Chem. Int. Ed. 2017, 56, 11624-11627. Highlighted by X-MOL and Synfacts.
49	Methodology Carbonylation	Yin, X.; Mohammad, H.; Eldesouky, H. E.; Abdelkhalek, A.; Seleem, M. N.;* Dai, M.* "Rapid Syntheses of Bicyclic Lactones via Palladium-Catalyzed Aminocarbonylative Lactonizations" Chem. Commun. 2017, 53, 7238-7241 (Invited contribution to the ChemComm Emerging Investigators Issue 2017). Highlighted by X-MOL.
48	Drug Discovery Antibiotic	Mohammad, H.†; Kyei-Baffour, K.†; Younis, W.; Davis, D. C.; Eldesouky, H.; Seleem, M. N.;* Dai, M.* "Investigation of Aryl Isonitrile Compounds with Potent, Broad-spectrum Antifungal Activity" Bioorg. Med. Chem. 2017, 25, 2926-2931. (†contributed equally; Invited contribution in honor of Professor Xiaoguang Lei’s Tetrahedron Young Investigator Award 2017).
47	Review Carbonylation	Bai, Y.; Davis, D. C.; Dai, M.* "Natural Product Synthesis via Palladium-Catalyzed Carbonylation" J. Org. Chem., 2017, 82, 2319-2328 (Invited JOCSynopsis contribution by Professor Dale Poulter).
46	Drug Discovery Pain	Brust, T. F.; Alongkronrusmee, D.; Soto-Velasquez, M.; Baldwin, T. A.; Ye, Z.; Dai, M.; Dessauer, C. W.; van Rijn, R. M.; Watts, V. J.* "Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties" Science Signaling, 2017, 10, eaah5381. Highlighted by Science News Story.
45	Review Heterocycles	Gettys, K. E.; Ye, Z.; Dai, M.* "Recent Advances in Piperazine Synthesis" Synthesis, 2017, 49, 2589-2604 (Invited review article by Professor Dieter Enders).
44	Methodology Cyclopropanol	Davis, D. C.; Haskins, C. W.; Dai, M.* "Radical Cyclopropanol Ring Opening Initiated Tandem Cyclizations for Efficient Synthesis of Phenanthridines and Oxindoles" Synlett, 2017, 28, 913-918 (Invited contribution for the special issue dedicated to the EuCheMS Young Investigator Workshop 2016).
43	Total Synthesis	Li, Y.; Wei, M. (UG); Dai, M.* "Gold Catalysis-Facilitated Rapid Synthesis of the Daphnane/Tigliane Tricyclic Core" Tetrahedron, 2017, 73, 4172-4177 (Invited contribution the "New Advances in Pericyclic Reactions" Symposium-in-Print guest-edited by Prof. Uttam Tambar).
42	Editorial	Dai, M.* “Harnessing Molecular Strain in Organic Synthesis and Related Fields” Curr. Org. Chem. 2016, 20, 1850-1850.
41	Total Synthesis	Bai, Y.; Shen, X. (UG); Li, Y.; Dai, M.* "Total Synthesis of Spinosyn A via Carbonylative Macrolactonization" J. Am. Chem. Soc. 2016, 138, 10838-10841. Highlighted by Synfacts and in the Today’s Topic of the Agricultural Chemical Society of Japan: 2017, Vol. 55, No. 8, 523-525.
40	Total Synthesis Methodology Carbonylation	Davis, D. C.; Walker, K. L.; Hu, C.; Zare, R. N.; Waymouth, R. M.*; Dai, M.* "Catalytic Carbonylative Spirolactonization of Hydroxycyclopropanols" J. Am. Chem. Soc. 2016, 138, 10693-10699. Highlighted by Organic Chemistry Portal.
39	Review Heterocycles	Ye, Z.; Gettys, K. E.; Dai, M.* "Opportunities and Challenges for Direct C-H Functionalization of Piperazines" Beilstein J. Org. Chem. 2016, 12, 702-715. (Invited for the Thematic Series "C-H Functionalization/Activation in Organic Synthesis"; Guest Editor: Prof. Richmond Sarpong)
38	Reaction Mechanism	Lin, Z.; Tan, L.; Yang Y.; Dai, M.; Tureček, F.*, Ouyang, Z.,* and Xia, Y.* "Gas-Phase Reactions of Cyclopropenylidene with Protonated Alkyl Amines" Analyst 2016, 2412-2417.
37	Methodology Cyclopropanol	Ye, Z.; Gettys, K. E.; Shen, X. (UG); Dai, M.* "Copper-Catalyzed Cyclopropanol Ring Opening Csp3-Csp3 Cross Couplings with (Fluoro)Alkyl Halides" Org. Lett. 2015, 17, 6074-6077.
36	ChemBio	Chou, D. H.-C.; Vetere, A.; Choudhary, A.; Scully, S. S.; Schenone, M.; Tang, A.; Gomez, R.; Burns, S. M.; Lundh, M.; Vital, T.; Comer, E.; Faloon, P. W.; Dancik, V.; Ciario, C.; Paulk, J.; Dai, M.; Reddy, C.; Sun, H.; Young, M.; Donato, N.; Jaffe, J.; Clemons, P. A.; Palmer, M.; Carr, S. A.; Schreiber, S. L.; Wagner, B. K.* "Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling" J. Am. Chem. Soc. 2015, 137, 7929-7934.
35	Drug Discovery Antibiotic	Davis, D. C.†; Mohammad, H.†; Kyei-Baffour, K.; Younis, W.; Creemer, C. N. (UG); Seleem, M. N.*; Dai, M.* "Discovery and Characterization of Aryl Isonitriles as A New Class of Compounds versus Methicillin- and Vancomycin-resistant Staphylococcus aureus" Eur. J. Med. Chem. 2015, 101, 384-390. (†contributed equally)
34	Review Total Synthesis	Bai, Y.; Dai, M.* "Strategies and Methods for the Synthesis of Anti-Cancer Natural Product Neopeltolide and Its Analogs" Curr. Org. Chem. 2015, 19, 871-885. (Invited contribution)
33	Methodology Cyclopropanol	Ye, Z.; Dai, M.* "An Umpolung Strategy for the Synthesis of beta-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols" Org. Lett. 2015, 17, 2190-2193. Highlighted by X-MOL.
32	Methodology Cyclopropanol	Li, Y.†; Ye, Z.†; Bellman, T. M.; Chi, T. (UG); Dai, M.* "Efficient Synthesis of beta-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols" Org. Lett. 2015, 17, 2186-2189. (†contributed equally) Highlighted by X-MOL and Synfacts.
31	Methodology Pd Catalysis	Ye, Z.; Brust, T. F.; Watts, V. J.*; Dai, M.* "Palladium-Catalyzed Regio- and Stereoselective gamma-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors" Org. Lett. 2015, 17, 892-895.
30	ChemBio Imaging	Lee, H. J.†; Zhang, W.(UG)†; Zhang, D.; Yang, Y.; Liu, B.; Barker, E. L; Buhman, K. K.; Slipchenko, L. V.; Dai, M.*; Cheng, J.-X.* "Assessing Cholesterol Storage in Live Cells and C. elegans by SRS Imaging of Phenyl-Diyne Cholesterol" Sci. Rep. 2015, 5, 7930. doi:10.1038/srep07930. (†contributed equally)
29	Highlight	Dai, M.* Bai, Y.; Dexter, D. C.; “Synthesis of tetrahydropyran- or tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations” Synthesis, 2014, 46, A120-A121 (Synform 2014/09).
28	Total Synthesis	Yang, Y.†; Bai, Y.†; Sun, S.(UG); Dai, M.* "Biosynthetically Inspired Divergent Approach to Monoterpene Indole Alkaloids: Total Synthesis of Mersicarpine, Leuconodines B and D, Leuconoxine, Melodinine E, Leuconolam, and Rhazinilam" Org. Lett. 2014, 16, 6216-6219. (†contributed equally) Top 20 most read article in Organic Letters November 2014; The 2015 Organic Letters Outstanding Author of the Year Lectureship Award winning paper; Highlighed by Synfacts.
27	Methodology Pd Catalysis	Zhang, W. (UG)†; Haskins, C. W.†; Yang, Y.; Dai, M.* "Synthesis of Nitriles via Palladium-Catalyzed Water Shuffling From Amides to Acetonitrile" Org. Biomol. Chem. 2014, 12, 9109-9112. (†contributed equally)
26	Review Total Synthesis	Yang, Y.; Dai, M.* "Total Synthesis of Lyconadins:Finding Efficiency and Diversity" Synlett 2014, 25, 2093-2098. (Invited contribution)
25	Total Synthesis Methodology Carbonylation	Bai, Y.; Davis, D. C.; Dai, M.* "Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonization" Angew. Chem. Int. Ed. 2014, 53, 6519-6522 (selected as a Very Important Paper). Featured in SYNFORM and highlighted by Organic Chemistry Portal.
24	Total Synthesis	Yang, Y.; Haskins, C. W.; Zhang, W. (UG); Low, P. L. (UG); Dai, M.* "Divergent total syntheses of lyconadins A and C" Angew. Chem. Int. Ed. 2014, 53, 3922-3925. Highlighted by Organic Chemistry Portal and Amphoteros.
23	Drug Discovery Cancer	Boskovic, Z. V.; Hussain, M. M.; Adams, D. J.; Dai, M., Schreiber, S. L. "Synthesis of piperlogs and analysis of their effects on cells" Tetrahedron, 2013, 69, 7559-7567. (Special issue to honor Professor Paul Wender on his receipt of the 2012 Tetrahedron Prize for Creativity in Organic Chemistry)
22	Drug Discovery Cancer	Hartwell, K. A.; Miller, P. G.; Mukherjee, S.; Kahn, A. R.; Stewart, A. L.; Logan, D. J.; Negri, J. M.; Duvet, M.; Järås, M.; Puram, R.; Dancik, V.; Al-Shahrour, F.; Kindler, T.; Tothova, Z.; Chattopadhyay, S.; Hasaka, T.; Narayan, R.; Dai. M.; Huang, C.; Shterental, S.; Chu, L. P.; Haydu J. K.; Shieh, J. H.; Steensma, D. P.; Munoz, B.; Bittker, J.; Shamji, A. F.; Clemons, P.; Tolliday, N. J.; Carpenter, A. E.; Gilliland, D. G.; Stern, A. M.; Moore, M. A. S.; Scadden, D. T.; Schreiber, S. L.; Ebert, B. L.; Golub, T. R. "Niche-based screening identifies small-molecule inhibitors of leukemia stem cells" Nat. Chem. Bio., 2013, 9, 840-848.
21	Book Chapter	Dai. M.*; Boskovic, Z. "Ruthenium complex of N,N’,N",-trimethyl-1,4,7-triazacyclononane and ruthenium complexes of cis-diaquabis (6,6’-dichloro-2,2’-bipyridine)", first update, Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents (Ed. Fuchs, P. L.), Wiley, 2013, 561-565.
20	ChemBio Drug Discovery Cancer	Adams, D. J.†; Dai, M.†; Pellegrino, G.; Wagner, B. K.; Stern, A. M.; Shamji, A. F.; Schreiber, S. L. "Synthesis, Cellular Evaluation, and Mechanism of Action of Piperlongumine Analogs" Proc. Natl. Acad. Sci. USA, 2012, 109, 15115. (†contributed equally)
19	Methodology Diels-Alder reaction	Peng, F.; Dai, M.; Angeles, A. R.; Danishefsky, S. J. "Permuting Diels-Alder and Robinson Annulation Stereopatterns" Chem. Sci. 2012, 3, 3076. (The 4th most-Accessed Article: August, 2012.)
18	Total Synthesis	Wang, Z.; Dai, M.; Park, P. K.; Danishefsky, S. J. "Synthetic studies toward (+)-cortistatin A" Tetrahedron, 2011, 67, 10249. (Special issue dedicated to Professor Gilbert Stork’s 90th birthday.)
17	Methodology Gold Catalysis	Luo, T.; Dai, M.; Zheng, S-L.; Schreiber, S. L. "Synthesis of α-Pyrones by Gold-Catalyzed Coupling Reactions" Org. Lett. 2011, 13, 2834.
16	Methodology Computation Diels-Alder reaction	Hayden, A. E.; DeChancie, J.; George, A. H.; Dai, M.; Yu, M. L.; Danishefsky, S. J.; Houk, K. N "Origins of the Regioselectivities in the Diels−Alder Reactions of Vinylindenes with 1,4-Quinone Monoketal and Acrolein Dienophiles" J. Org. Chem. 2009, 74, 6770.
15	Total Synthesis	Dai, M.; Danishefsky, S. J. "An oxidative dearomatization cyclization model for cortistatin A" Heterocycles 2009, 77, 157. (Special issue dedicated to Dr. Keiichiro Fukumoto’s 75th birthday)
14	Total Synthesis	Dai, M.; Krauss, J. I.; Danishefsky, S. J. "Total synthesis of Spirotenuipesines A and B" J. Org. Chem. 2008, 73, 9576. (Special issue in the memory of Professor A. I. Meyers.)
13	Total Synthesis Methodology	Dai, M.; Wang, Z.; Danishefsky, S. J. "A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6613.
12	Total Synthesis	Dai, M.; Danishefsky, S. J. "A concise synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6610.
11	Total Synthesis	Lei, X. G.; Dai, M.; Hua, Z. H.; Danishefsky, S. J. "Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers" Tetrahedron Lett. 2008, 49, 6383.
10	Total Synthesis	Li. Z. T.; Gao, Y. X.; Tang, Y. F.; Dai, M.; Wang G. X.; Wang, Z. D.; Yang, Z. "Total synthesis of crisamicin A" Org. Lett. 2008, 10, 3017.
9	Total Synthesis	Dai, M.; Danishefsky, S. J. "The total synthesis of spirotenuipesines A and B" J. Am. Chem. Soc. 2007, 129, 3498. The 3rd most-Accessed Articles: January-March, 2007; the 6th most-Accessed Articles: 2007; Highlighted by JACS Virtual Issue "The Synthesis of Biologically Active Natural Products" J. Am. Chem. Soc. 2008, 130, 6654; Highlighted by Synfacts, 2007, 08, 0783.
8	Methodology Diels-Alder reaction	Dai, M.; Sarlah, D.; Yu, M. L.; Danishefsky, S. J.; Jones, G. J.; Houk, K. N. "Highly selective Diels-Alder reactions of directly connected enyne dienophiles" J. Am. Chem. Soc. 2007, 129, 645. Highlighted by Organic Chemistry Portal ID: J48-Y2007-0160.
7	Methodology Diels-Alder reaction	Liu, Y. X.; Lu, K.; Dai, M.; Wang, K.; Wu, W. Q.; Chen, J. H.; Quan, J. M.; Yang, Z. "An efficient one-pot asymmetric synthesis of biaryl compounds via Diels-Alder/retro-Diels-Alder cascade reactions" Org. Lett. 2007, 9, 805.
6	Total Synthesis	Tang, Y. F.; Zhang, Y. D.; Dai, M.; Luo, T. P.; Deng, L. J.; Chen, J. H.; Yang, Z. "A highly efficient synthesis of the FGH ring of micrandilactone A: Application of thioureas as ligands in the Co-catalyzed Pauson-Khand reaction and Pd-catalyzed carbonylative annulation" Org. Lett. 2005, 7, 885.
5	Methodology Pd Catalysis	Liang, B.; Dai, M.; Chen. J. H.; Yang, Z. "Copper-free Sonogashira coupling reaction with PdCl2 in water under aerobic conditions" J. Org. Chem. 2005, 70, 391. The 10th most-Accessed Articles: January-March, 2005; the 12th most-Accessed Articles: 2005; Highlighted by Organic Chemistry Portal ID: J42-Y2005-090.
4	Methodology Pd Catalysis	Xiong, Z.-C.; Wang, N.-D.; Dai, M.; Li, A.; Chen. J. H.; Yang, Z. "Synthesis of novel palladacycles and their application in the Heck and Suzuki reaction under aerobic conditions" Org. Lett. 2004, 6, 3337.
3	Methodology Pd Catalysis	Dai, M.; Liang, B.; Wang, C. H.; You, Z. J.; Xiang, J.; Dong, G. B.; Chen. J. H.; Yang, Z. "A novel thiourea ligand applied in Heck, Suzuki and Suzuki carbonylative reactions" Adv. Synth. Catal. 2004, 346, 1669.
2	Methodology Pd Catalysis	Dai, M.; Liang, B.; Wang, C. H.; Chen. J. H.; Yang, Z. "Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions" Org. Lett. 2004, 6, 221.
1	Methodology Pd Catalysis	Dai, M.; Wang, C. H.; Dong, G. B.; Xiang, J.; Luo, T. P.; Liang, B.; Chen. J. H.; Yang, Z. "Development of thiourea-based ligands for the palladium-catalyzed bis(methoxycarbonylation) of terminal olefins" Eur. J. Org. Chem. 2003, 4346.