Chen, Z.; Chen, F.; Lee, H. J.; Zhang, M.; Yin, X.; Dai, M.; Cheng, J.-X.* “LIPA-Driven Hydrolysis of Cholesteryl Arachidonate Promotes Cancer Metastasis via NF-κB” bioRxiv (DOI:
95Natural Product Drug Discovery Liang, W.; Krabill, A. D.; Gallagher, K. S.; Muli, C.; Qu, Z.; Trader, D.; Zhang, Z.-Y.;* Dai, M.* “Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase” Tetrahedron, 2024, 155, accepted. (Invited contribution to the special issue in honor of Professor Thomas Maimone’s 2024 Tetrahedron Young Investigator Award in Organic Synthesis)
94MethodologyFang, W.; Luo, Z.-W.; Wang, Y.-C.; Zhou, W.; Li, L.; Chen, Y.; Zhang, X.; Dai, M.;* Dai, J.-J.* “An SN2 reaction at amide nitrogen enables hydrazide synthesis”. Angew. Chem. Int. Ed. 2024, 63, e202317570.
93Total SynthesisJin, Y.; Hok, S.; Bacsa, J.; Dai, M.* “Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C-H Functionalizations” J. Am. Chem. Soc. 2024, 146, 1825-1831..
92Total SynthesisJiang, B.; Dai, M.* "Concise Total Syntheses of the 6-7-5 Hamigeran Natural Products". J. Am. Chem. Soc. 2023, 145, 18731-18736.
91Total SynthesisCui, C.; Dai, M.* "Total Synthesis of UCS1025A via Tandem Carbonylative Stills Cross Coupling and Diels-Alder Reaction". Chin. J. Chem. 2023, doi: 10.1002/cjoc.202300331. (Invited contribution dedicated to the Special Issue of C1 Chemistry).
90Total SynthesisMartin, B. S.†; Ma, D.†; Saito, T.; Gallagher, K. S.; Dai, M.* "Concise Total Synthesis of Complanadine A Enabled by Pyrrole-to-Pyridine Molecular Editing". Synthesis, 2023, accepted (DOI: 10.1055/a-2107-5159).
(†contributed equally)
89Total SynthesisCai, X.;† Li, L.;† Wang, Y.-C.; Zhou, J.; Dai, M.* "Total Syntheses of Phleghenrines A and C". Org. Lett. 2023, 25, 5258-5261. (†contributed equally)

Previous deposit at ChemRxiv:
ChemRxiv, May 26, 2023. DOI: 10.26434/chemrxiv-2023-8f4rz.
Dai, J.-J;† Yin, X.;† Li, L.;† Rivera, M. E.; Wang, Y.-C.;* Dai, M.* " Modular and practical diamination of Allenes". Nature Communications, 2023, 14, 1774. (†contributed equally)
87PerspectiveSims, H. S.; Dai, M.* "Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments". J. Org. Chem. 2023, 88, 4925-4941.
86SpotlightSims, H. S.*; Dai, M.* "Taming PRMT5-adaptor protein interactions" Trends Pharmacol. Sci. 2023, 44, 134-136.
85Total SynthesisLi, L.; Liang, W.; Rivera, M. E.; Wang, Y.-C.; Dai, M. "Concise Synthesis of (-)-GA18 Methyl Ester" J. Am. Chem. Soc. 2023, 145, 53-57.
84Total SynthesisXu, B.;† Liu, C.;† Dai, M.;* “Catalysis-Enabled 13-Step Total Synthesis of (-)-Peyssonnoside A” J. Am. Chem. Soc. 2022, 144, 19700-19703. (†contributed equally)
83Drug Discovery
Asberry, A. M.†; Cai, X.†; Deng, X.†; Santiago, U.†; Liu, S.; Sims, H. S.; Liang, W.; Xu, X.; Wan, J.; Jiang, W.; Camacho, C.;* Dai, M.;* Hu, C.-D.* “Discovery and biological characterization of PRMT5:MEP50 protein-protein interaction inhibitors” J. Med. Chem. 2022, 65, 13793-13812. (†contributed equally)
Clark, M. G.; Gonzalez, G.; Luo, Y.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G.; Dai, M. Zhang, C.* "Real-Time Precision Opto-Control of Chemical Processes in Live Cells" Nature Communications, 2022, 13, 4343.
Nickel Catalysis
de Andrade Horn, P.; Sims, H. S. Dai, M.* "Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes" J. Org. Chem. 2022, 87, 8796-8801.
80Drug Discovery
Peery, R.; Cui, Q.; Kyei-Baffour, K.; Josephraj, S.; Huang, C.; Dong, Z.; Dai, M.;* Zhang, J.-T.* Liu, J.-Y.;* “A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells” Bioorg. Med. Chem. 2022, 65, 116761.
79Book Chapter
Luo, Y.; Li, L.; Dai, M.* “Complex Natural Products Total Syntheses Facilitated by Palladium-Catalyzed Carbonylative Cyclizations” in “The Chemical Transformations of C1 Compounds”, Volume 2, Chapter 18, 793-826, Book Editors: Kuling Ding, Xiao-Feng Wu, Buxing Han, Zhongmin Liu, Wiley.
78Total SynthesisSims, H. S.; de Andrade Horn, P.; Isshiki, R.; Lim, M. (UG); Xu, Y.; Grubbs, R. H.; Dai, M* "Catalysis-Enabled Concise and Stereoselective Total Synthesis of the Tricyclic Prostaglandin D2 Metabolite Methyl Ester" Angew. Chem. Int. Ed., 2022, 61, e202115633.
77Total SynthesisJiang, B.; Dai, M.* “11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C-H Functionalizations" J. Am. Chem. Soc. 2021, 143, 20084-20089.
76Total SynthesisMa, D.†; Martin, B. S.†; Gallagher S. K. (UG); Saito, T. (UG); Dai, M.* “One-Carbon Insertion and Polarity Inversion Enabled a Pyrrole Strategy to the Total Syntheses of Pyridine-Containing Lycopodium Alkaloids: Complanadine A and Lycodine” J. Am. Chem. Soc. 2021, 143, 16383-16387. (†contributed equally)
75Total SynthesisWang, Y.-C.†; Cui, C.†; Dai, M.* "Flow Chemistry-Enabled Divergent and Enantioselective Total Syntheses of Massarinolin A, Purpurolides B, D, E, 2,3-Deoxypurpurolide C, and Structural Revision of Massarinolin A" Angew. Chem. Int. Ed. 2021, 60, 24828-24832. (†contributed equally)

Selected as a Hot Paper; Featured as an Inside Cover; Highlighted by WileyChem.
74Drug Discovery
Negi, V.; Yang, J.; Speyer, G.; Pulgarin, A.; Handen, A.; Zhao, J.; Tai, Y. Y.; Tang, Y.; Culley, M. K.; Yu, Q.; Forsythe, P.; Gorelova, A.; Watson, A. M.; Aaraj, Y. A.; Satoh, T.; Sharifi-Sanjani, M.; Rajaratnam, A.; Sembrat, J.; Provencher, S.; Yin, X.; Vargas, S. O.; Rojas, M.; Bonnet, S.; Torrino, S.; Wagner, B. K.; Schreiber, S. L.; Dai, M.; Bertero, T.; Ghouleh, I. A.; Kim, S.; Chan, S. Y.* “Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension” Science Advances, 2021, 7:eabh3794.
73Drug Discovery
Pal, R.; Dai, M.; Seleem, M. N.* “High-throughput screening identifies a novel natural product-inspired molecule inhibiting Clostridioides difficile in vitro and in vivo” Sci. Rep. 2021, 11, 10913.
72Total Synthesis
Target ID
Cui, C.†; Dwyer, B. G.†; Liu, C.; Abegg, D.; Cai, Z.; Hoch, D.; Yin, X.; Qiu, N.; Liu, J.; Adibekian, A.;* Dai, M.* "Total Synthesis and Target Identification of the Curcusone Diterpenes " J. Am. Chem. Soc. 2021, 143, 4379-4386. (†contributed equally.)

Featured in Purdue News, ScienceDaily, NSF Research News, and others; Highlighted by X-MOL and Synfacts.
71ChemBioRaffa, N.; Won, T. H.; Sukowaty A.; Candor, K.; Cui, C.; Halder, S.; Dai, M.; Figueroa, J. A. L.; Schroeder, F. C.; Keller, N. P.* "Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity" Proc. Natl. Acad. Sci. USA, 2021, 118, e2015224118.
Liang, W.; Cai, X.; Dai, M.* "Cu-Catalyzed Hydroxycyclopropanol Ring-Opening Cyclization to Tetrahydrofurans and Tetrahydropyrans: Short Total Syntheses of Hyperiones" Chem. Sci. 2021, 12, 1311.

Highlighted by X-MOL
Cai, X.; Liang, W.; Liu, M. (UG); Li, X. (UG); Dai, M.* "Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones" J. Am. Chem. Soc. 2020, 142, 13677-13682.

Highlighted by X-MOL and Synfacts
68Drug Discovery
Kyei-Baffour, K.; Davis, D. C.; Boskovic, Z.; Kato, N.;* Dai, M.* "Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug resistant parasites" Bioorg. Med. Chem. 2020, 28, article 115678.
67Total SynthesisYin, X.; Ma, K.; Dong, Y. (UG); Dai, M.* "Pyrrole Strategy to the γ-Lactam-Containing Stemona Alkaloids: (±)-Stemoamide, (±)-Tuberostemoamide, and (±)-Sessilifoliamide A" Org. Lett. 2020, 22, 5001-5004.
66Drug Discovery
Peery, R.; Kyei-Baffour, K.; Dong, Z.; de Andrade Horn, P.; Dai, M.;* Liu, J.;* Zhang, J.* “Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation” J. Med. Chem. 2020, 63, 7243-7251.
65Total SynthesisJiang, B.; Dai, M.* “Synthetic Studies towards the Hamigerans with a 6-7-5 Tricyclic Core” Org. Lett. 2020, 22, 4176-4179.
64ChemBioHuang, L.; Li, X.; Zhang, W.; Ung, N.; Liu, N.; Yin, X.; Li, Y.; Mcewan, R. E.; Dilkes, B.; Dai, M.; Hicks, G. R.; Raikhel, N. V.; Staiger, C. J. Zhang, C.* “Endosidin20 Targets the Cellulose Synthase Catalytic Domain to Inhibitor Cellulose Biosynthesis” Plant Cell, 2020, 32, 2141-2157.
63Material ChemistryOleson, A.; Zhu, T.; Dunn, I.; Bialas, D.; Bai, Y.; Zhang, W.; Dai, M.; Reichman, D.; Tempelaar, R.; Huang, L.; Spano, F.* “Perylene Diimide- Based Hj- and hJ-Aggregates: The Prospect of Exciton Band Shape Engineering in Organic Materials” J. Phys. Chem. C 2019, 123, 20567-20578.
62ChemBioHuang, L.; Li, X.; Li, Y.; Yin, X.; Li, Y.; Wu, B.; Mo, H.; Liao, C.; Mengiste, T.; Guo, W.; Dai, M.; Zhang, C.* “Endosidin2-14 targets the exocyst complex in plants and fungal pathogens to inhibit exocytosis” Plant Physiology 2019,180, 1756-1770.
61Drug Discovery
Mohammad, H.†; Kyei-Baffour, K.†; Abutaleb, N. S.; Dai, M.*; Seleem, M.* "An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection" J. Glob. Antimicrob. Resist. 2019, 1-7 (doi:10.1016/j.jgar.2019.04.016). (†contributed equally)
60Drug Discovery
Kyei-Baffour, K.†; Mohammad, H.†; Seleem, M.*; Dai, M.* "Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus" Bioorg. Med. Chem. 2019, 27, 1845-1854. (†contributed equally)
59Total SynthesisLuo, Y.; Yin, X.; Dai, M.* "Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation" J. Antibiotics 2019, 72, 482-485. (Special Issue dedicated to Professor Samuel J. Danishefsky)
Cai, X.; Liang, W.; Dai, M.* "Total Syntheses via Cyclopropanols" Tetrahedron 2019, 75, 193-208. (Invited Special Issue Paper: Recent Applications of Metal Catalysis in Natural Product Synthesis. Guest Editors: Jeremy May and John Wood)
57Total Synthesis
Target ID
Davis, D. C.†; Hoch, D. G.†; Wu, L.; Abegg, D.; Martin, B. S. Zhang, Z.-Y.*; Adibekian, A.*; Dai, M.* "Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids" J. Am. Chem. Soc. 2018, 140, 17465-17473. (†These authors contributed equally.)
56Total SynthesisMa, K.†; Yin, X. L.†; Dai, M.* "Total Syntheses of Bisdehydroneostemoninine and Bisdehydrostemoninine by Catalytic Carbonylative Spirolactonization" Angew. Chem. Int. Ed. 2018, 57, 15209-15212. (†contributed equally.)

Highlighted by Synfacts.
Total Synthesis
Cai, X.; Bai, Y.; Dai, M.* "Total Syntheses of Spinosyn A" Synlett 2018, 2623-2632. (Invited Synlett Account contribution by Prof. Peter Vollhardt)
Total Synthesis
Ma, K.†; Martin, B. S.†; Yin, X. L.†; Dai, M.* "Natural Product Syntheses via Carbonylative Cyclizations" Nat. Prod. Rep. 2019, 36, 174-219. (†contributed equally)

Highlighted by X-MOL.
Ye, Z.†; Cai, X.†; Li, J. (UG), Dai, M.* "Catalytic Cyclopropanol Ring Opening for Divergent Syntheses of gamma-Butyrolactones and delta-Ketoesters Containing All-Carbon Quaternary Centers" ACS Catalysis 2018, 8, 5907-5914. (†contributed equally)

Highlighted by X-MOL.
Ye, Z.; Adhikari, S.; Xia, Y.*; Dai, M.* "Expedient Syntheses of N-Heterocycles via Intermolecular Amphoteric Diamination of Allenes" Nature Communications 2018, 9, 721.

Highlighted by X-MOL and Synfacts.
51ReviewLi, Y.; Yin, X. L.; Dai, M.* "Catalytic Macrolactonizations for Natural Product Synthesis" Nat. Prod. Rep. 2017, 34, 1185-1192.

Featured as Front Cover.
50Total SynthesisLi, Y.; Dai, M.* "Total Syntheses of the Reported Structures of Curcusone I and J through Tandem Gold Catalysis" Angew. Chem. Int. Ed. 2017, 56, 11624-11627.

Highlighted by X-MOL and Synfacts.
Yin, X.; Mohammad, H.; Eldesouky, H. E.; Abdelkhalek, A.; Seleem, M. N.;* Dai, M.* "Rapid Syntheses of Bicyclic Lactones via Palladium-Catalyzed Aminocarbonylative Lactonizations" Chem. Commun. 2017, 53, 7238-7241 (Invited contribution to the ChemComm Emerging Investigators Issue 2017).

Highlighted by X-MOL.
48Drug Discovery
Mohammad, H.†; Kyei-Baffour, K.†; Younis, W.; Davis, D. C.; Eldesouky, H.; Seleem, M. N.;* Dai, M.* "Investigation of Aryl Isonitrile Compounds with Potent, Broad-spectrum Antifungal Activity" Bioorg. Med. Chem. 2017, 25, 2926-2931. (†contributed equally; Invited contribution in honor of Professor Xiaoguang Lei’s Tetrahedron Young Investigator Award 2017).
Bai, Y.; Davis, D. C.; Dai, M.* "Natural Product Synthesis via Palladium-Catalyzed Carbonylation" J. Org. Chem., 2017, 82, 2319-2328 (Invited JOCSynopsis contribution by Professor Dale Poulter).
46Drug Discovery
Brust, T. F.; Alongkronrusmee, D.; Soto-Velasquez, M.; Baldwin, T. A.; Ye, Z.; Dai, M.; Dessauer, C. W.; van Rijn, R. M.; Watts, V. J.* "Identification of a selective small molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties" Science Signaling, 2017, 10, eaah5381.

Highlighted by Science News Story.
Gettys, K. E.; Ye, Z.; Dai, M.* "Recent Advances in Piperazine Synthesis" Synthesis, 2017, 49, 2589-2604 (Invited review article by Professor Dieter Enders).
Davis, D. C.; Haskins, C. W.; Dai, M.* "Radical Cyclopropanol Ring Opening Initiated Tandem Cyclizations for Efficient Synthesis of Phenanthridines and Oxindoles" Synlett, 2017, 28, 913-918 (Invited contribution for the special issue dedicated to the EuCheMS Young Investigator Workshop 2016).
43Total SynthesisLi, Y.; Wei, M. (UG); Dai, M.* "Gold Catalysis-Facilitated Rapid Synthesis of the Daphnane/Tigliane Tricyclic Core" Tetrahedron, 2017, 73, 4172-4177 (Invited contribution the "New Advances in Pericyclic Reactions" Symposium-in-Print guest-edited by Prof. Uttam Tambar).
42EditorialDai, M.* “Harnessing Molecular Strain in Organic Synthesis and Related Fields” Curr. Org. Chem. 2016, 20, 1850-1850.
41Total SynthesisBai, Y.; Shen, X. (UG); Li, Y.; Dai, M.* "Total Synthesis of Spinosyn A via Carbonylative Macrolactonization" J. Am. Chem. Soc. 2016, 138, 10838-10841.

Highlighted by Synfacts and in the Today’s Topic of the Agricultural Chemical Society of Japan: 2017, Vol. 55, No. 8, 523-525.
40Total Synthesis
Davis, D. C.; Walker, K. L.; Hu, C.; Zare, R. N.; Waymouth, R. M.*; Dai, M.* "Catalytic Carbonylative Spirolactonization of Hydroxycyclopropanols" J. Am. Chem. Soc. 2016, 138, 10693-10699.

Highlighted by Organic Chemistry Portal.
Ye, Z.; Gettys, K. E.; Dai, M.* "Opportunities and Challenges for Direct C-H Functionalization of Piperazines" Beilstein J. Org. Chem. 2016, 12, 702-715. (Invited for the Thematic Series "C-H Functionalization/Activation in Organic Synthesis"; Guest Editor: Prof. Richmond Sarpong)
38Reaction MechanismLin, Z.; Tan, L.; Yang Y.; Dai, M.; Tureček, F.*, Ouyang, Z.,* and Xia, Y.* "Gas-Phase Reactions of Cyclopropenylidene with Protonated Alkyl Amines" Analyst 2016, 2412-2417.
Ye, Z.; Gettys, K. E.; Shen, X. (UG); Dai, M.* "Copper-Catalyzed Cyclopropanol Ring Opening Csp3-Csp3 Cross Couplings with (Fluoro)Alkyl Halides" Org. Lett. 2015, 17, 6074-6077.
36ChemBioChou, D. H.-C.; Vetere, A.; Choudhary, A.; Scully, S. S.; Schenone, M.; Tang, A.; Gomez, R.; Burns, S. M.; Lundh, M.; Vital, T.; Comer, E.; Faloon, P. W.; Dancik, V.; Ciario, C.; Paulk, J.; Dai, M.; Reddy, C.; Sun, H.; Young, M.; Donato, N.; Jaffe, J.; Clemons, P. A.; Palmer, M.; Carr, S. A.; Schreiber, S. L.; Wagner, B. K.* "Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling" J. Am. Chem. Soc. 2015, 137, 7929-7934.
35Drug Discovery
Davis, D. C.†; Mohammad, H.†; Kyei-Baffour, K.; Younis, W.; Creemer, C. N. (UG); Seleem, M. N.*; Dai, M.* "Discovery and Characterization of Aryl Isonitriles as A New Class of Compounds versus Methicillin- and Vancomycin-resistant Staphylococcus aureus" Eur. J. Med. Chem. 2015, 101, 384-390. (†contributed equally)
Total Synthesis
Bai, Y.; Dai, M.* "Strategies and Methods for the Synthesis of Anti-Cancer Natural Product Neopeltolide and Its Analogs" Curr. Org. Chem. 2015, 19, 871-885. (Invited contribution)
Ye, Z.; Dai, M.* "An Umpolung Strategy for the Synthesis of beta-Aminoketones via Copper-Catalyzed Electrophilic Amination of Cyclopropanols" Org. Lett. 2015, 17, 2190-2193.

Highlighted by X-MOL.
Li, Y.†; Ye, Z.†; Bellman, T. M.; Chi, T. (UG); Dai, M.* "Efficient Synthesis of beta-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols" Org. Lett. 2015, 17, 2186-2189. (†contributed equally)

Highlighted by X-MOL and Synfacts.
Pd Catalysis
Ye, Z.; Brust, T. F.; Watts, V. J.*; Dai, M.* "Palladium-Catalyzed Regio- and Stereoselective gamma-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors" Org. Lett. 2015, 17, 892-895.
Lee, H. J.†; Zhang, W.(UG)†; Zhang, D.; Yang, Y.; Liu, B.; Barker, E. L; Buhman, K. K.; Slipchenko, L. V.; Dai, M.*; Cheng, J.-X.* "Assessing Cholesterol Storage in Live Cells and C. elegans by SRS Imaging of Phenyl-Diyne Cholesterol" Sci. Rep. 2015, 5, 7930. doi:10.1038/srep07930. (†contributed equally)
29HighlightDai, M.* Bai, Y.; Dexter, D. C.; “Synthesis of tetrahydropyran- or tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations” Synthesis, 2014, 46, A120-A121 (Synform 2014/09).
28Total SynthesisYang, Y.†; Bai, Y.†; Sun, S.(UG); Dai, M.* "Biosynthetically Inspired Divergent Approach to Monoterpene Indole Alkaloids: Total Synthesis of Mersicarpine, Leuconodines B and D, Leuconoxine, Melodinine E, Leuconolam, and Rhazinilam" Org. Lett. 2014, 16, 6216-6219. (†contributed equally)

Top 20 most read article in Organic Letters November 2014; The 2015 Organic Letters Outstanding Author of the Year Lectureship Award winning paper; Highlighed by Synfacts.
Pd Catalysis
Zhang, W. (UG)†; Haskins, C. W.†; Yang, Y.; Dai, M.* "Synthesis of Nitriles via Palladium-Catalyzed Water Shuffling From Amides to Acetonitrile" Org. Biomol. Chem. 2014, 12, 9109-9112. (†contributed equally)
Total Synthesis
Yang, Y.; Dai, M.* "Total Synthesis of Lyconadins:Finding Efficiency and Diversity" Synlett 2014, 25, 2093-2098. (Invited contribution)
25Total Synthesis
Bai, Y.; Davis, D. C.; Dai, M.* "Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonization" Angew. Chem. Int. Ed. 2014, 53, 6519-6522 (selected as a Very Important Paper).

Featured in SYNFORM and highlighted by Organic Chemistry Portal.
24Total SynthesisYang, Y.; Haskins, C. W.; Zhang, W. (UG); Low, P. L. (UG); Dai, M.* "Divergent total syntheses of lyconadins A and C" Angew. Chem. Int. Ed. 2014, 53, 3922-3925.

Highlighted by Organic Chemistry Portal and Amphoteros.
23Drug Discovery
Boskovic, Z. V.; Hussain, M. M.; Adams, D. J.; Dai, M., Schreiber, S. L. "Synthesis of piperlogs and analysis of their effects on cells" Tetrahedron, 2013, 69, 7559-7567. (Special issue to honor Professor Paul Wender on his receipt of the 2012 Tetrahedron Prize for Creativity in Organic Chemistry)
22Drug Discovery
Hartwell, K. A.; Miller, P. G.; Mukherjee, S.; Kahn, A. R.; Stewart, A. L.; Logan, D. J.; Negri, J. M.; Duvet, M.; Järås, M.; Puram, R.; Dancik, V.; Al-Shahrour, F.; Kindler, T.; Tothova, Z.; Chattopadhyay, S.; Hasaka, T.; Narayan, R.; Dai. M.; Huang, C.; Shterental, S.; Chu, L. P.; Haydu J. K.; Shieh, J. H.; Steensma, D. P.; Munoz, B.; Bittker, J.; Shamji, A. F.; Clemons, P.; Tolliday, N. J.; Carpenter, A. E.; Gilliland, D. G.; Stern, A. M.; Moore, M. A. S.; Scadden, D. T.; Schreiber, S. L.; Ebert, B. L.; Golub, T. R. "Niche-based screening identifies small-molecule inhibitors of leukemia stem cells" Nat. Chem. Bio., 2013, 9, 840-848.
21Book ChapterDai. M.*; Boskovic, Z. "Ruthenium complex of N,N’,N",-trimethyl-1,4,7-triazacyclononane and ruthenium complexes of cis-diaquabis (6,6’-dichloro-2,2’-bipyridine)", first update, Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents (Ed. Fuchs, P. L.), Wiley, 2013, 561-565.
Drug Discovery
Adams, D. J.†; Dai, M.†; Pellegrino, G.; Wagner, B. K.; Stern, A. M.; Shamji, A. F.; Schreiber, S. L. "Synthesis, Cellular Evaluation, and Mechanism of Action of Piperlongumine Analogs" Proc. Natl. Acad. Sci. USA, 2012, 109, 15115. (†contributed equally)
Diels-Alder reaction
Peng, F.; Dai, M.; Angeles, A. R.; Danishefsky, S. J. "Permuting Diels-Alder and Robinson Annulation Stereopatterns" Chem. Sci. 2012, 3, 3076. (The 4th most-Accessed Article: August, 2012.)
18Total SynthesisWang, Z.; Dai, M.; Park, P. K.; Danishefsky, S. J. "Synthetic studies toward (+)-cortistatin A" Tetrahedron, 2011, 67, 10249. (Special issue dedicated to Professor Gilbert Stork’s 90th birthday.)
Gold Catalysis
Luo, T.; Dai, M.; Zheng, S-L.; Schreiber, S. L. "Synthesis of α-Pyrones by Gold-Catalyzed Coupling Reactions" Org. Lett. 2011, 13, 2834.
Diels-Alder reaction
Hayden, A. E.; DeChancie, J.; George, A. H.; Dai, M.; Yu, M. L.; Danishefsky, S. J.; Houk, K. N "Origins of the Regioselectivities in the Diels−Alder Reactions of Vinylindenes with 1,4-Quinone Monoketal and Acrolein Dienophiles" J. Org. Chem. 2009, 74, 6770.
15Total SynthesisDai, M.; Danishefsky, S. J. "An oxidative dearomatization cyclization model for cortistatin A" Heterocycles 2009, 77, 157. (Special issue dedicated to Dr. Keiichiro Fukumoto’s 75th birthday)
14Total SynthesisDai, M.; Krauss, J. I.; Danishefsky, S. J. "Total synthesis of Spirotenuipesines A and B" J. Org. Chem. 2008, 73, 9576. (Special issue in the memory of Professor A. I. Meyers.)
13Total Synthesis
Dai, M.; Wang, Z.; Danishefsky, S. J. "A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6613.
12Total SynthesisDai, M.; Danishefsky, S. J. "A concise synthesis of the cortistatin core" Tetrahedron Lett. 2008, 49, 6610.
11Total SynthesisLei, X. G.; Dai, M.; Hua, Z. H.; Danishefsky, S. J. "Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers" Tetrahedron Lett. 2008, 49, 6383.
10Total SynthesisLi. Z. T.; Gao, Y. X.; Tang, Y. F.; Dai, M.; Wang G. X.; Wang, Z. D.; Yang, Z. "Total synthesis of crisamicin A" Org. Lett. 2008, 10, 3017.
9Total SynthesisDai, M.; Danishefsky, S. J. "The total synthesis of spirotenuipesines A and B" J. Am. Chem. Soc. 2007, 129, 3498.

The 3rd most-Accessed Articles: January-March, 2007; the 6th most-Accessed Articles: 2007; Highlighted by JACS Virtual Issue "The Synthesis of Biologically Active Natural Products" J. Am. Chem. Soc. 2008, 130, 6654; Highlighted by Synfacts, 2007, 08, 0783.
Diels-Alder reaction
Dai, M.; Sarlah, D.; Yu, M. L.; Danishefsky, S. J.; Jones, G. J.; Houk, K. N. "Highly selective Diels-Alder reactions of directly connected enyne dienophiles" J. Am. Chem. Soc. 2007, 129, 645.

Highlighted by Organic Chemistry Portal ID: J48-Y2007-0160.
Diels-Alder reaction
Liu, Y. X.; Lu, K.; Dai, M.; Wang, K.; Wu, W. Q.; Chen, J. H.; Quan, J. M.; Yang, Z. "An efficient one-pot asymmetric synthesis of biaryl compounds via Diels-Alder/retro-Diels-Alder cascade reactions" Org. Lett. 2007, 9, 805.
6Total SynthesisTang, Y. F.; Zhang, Y. D.; Dai, M.; Luo, T. P.; Deng, L. J.; Chen, J. H.; Yang, Z. "A highly efficient synthesis of the FGH ring of micrandilactone A: Application of thioureas as ligands in the Co-catalyzed Pauson-Khand reaction and Pd-catalyzed carbonylative annulation" Org. Lett. 2005, 7, 885.
Pd Catalysis
Liang, B.; Dai, M.; Chen. J. H.; Yang, Z. "Copper-free Sonogashira coupling reaction with PdCl2 in water under aerobic conditions" J. Org. Chem. 2005, 70, 391.

The 10th most-Accessed Articles: January-March, 2005; the 12th most-Accessed Articles: 2005; Highlighted by Organic Chemistry Portal ID: J42-Y2005-090.
Pd Catalysis
Xiong, Z.-C.; Wang, N.-D.; Dai, M.; Li, A.; Chen. J. H.; Yang, Z. "Synthesis of novel palladacycles and their application in the Heck and Suzuki reaction under aerobic conditions" Org. Lett. 2004, 6, 3337.
Pd Catalysis
Dai, M.; Liang, B.; Wang, C. H.; You, Z. J.; Xiang, J.; Dong, G. B.; Chen. J. H.; Yang, Z. "A novel thiourea ligand applied in Heck, Suzuki and Suzuki carbonylative reactions" Adv. Synth. Catal. 2004, 346, 1669.
Pd Catalysis
Dai, M.; Liang, B.; Wang, C. H.; Chen. J. H.; Yang, Z. "Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions" Org. Lett. 2004, 6, 221.
Pd Catalysis
Dai, M.; Wang, C. H.; Dong, G. B.; Xiang, J.; Luo, T. P.; Liang, B.; Chen. J. H.; Yang, Z. "Development of thiourea-based ligands for the palladium-catalyzed bis(methoxycarbonylation) of terminal olefins" Eur. J. Org. Chem. 2003, 4346.